Catenin beta Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC;IF
| Verified Samples |
Verified Samples in WB:HCT116,Mouse lung,Mouse brain,Rat brain Verified Samples in IHC:Human colon,Mouse kidney,Human colon Verified Samples in IF:Mouse stomach |
| Dilution | WB 1:500-1:2000;IHC 1:300-1:1000;IF 1:200-1:800 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse β-catenin |
| Abbre | Catenin beta |
| Synonyms | Beta catenin;Beta-catenin;Cadherin associated protein;Catenin (cadherin associated protein);beta 1;88kDa;Catenin beta 1;Catenin beta-1;CATNB;CHBCAT;CTNB1;CTNNB;CTNNB1;DKFZp686D02253;FLJ25606;FLJ37923;OTTHUMP00000162082;OTTHUMP00000165222;OTTHUMP00000165223;OTTHUMP00000209288;OTTHUMP00000209289抗体 |
| Swissprot | |
| Calculated MW | 92kDa |
| Observed MW | 92kDa |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasm>cytoskeleton. Cell junction>adherens junction. Cell junction. Cell membrane. Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. |
| Concentration | 0.97 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Cardiovascular; Neuroscience; Signal Transduction; Stem Cells |
| Conjugation | Unconjugated |
| Background | CTNNB1,also known as β-Catenin,is an evolutionarily conserved,multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs,CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. . |
Western Blot analysis of various samples using Catenin beta Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded Human colon tissue using Catenin beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Mosue kidney using Catenin beta Polyclonal Antibody at dilution of 1:500.
Immunofluorescence analysis of Mouse stomach using Catenin beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Human Colon using Catenin beta Polyclonal Antibody(Elabscience Product Detected by Lifespan).
