HRAS Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human; Mouse; Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:Mouse brain,SKOV3,Rat brain,Mouse kidney Verified Samples in IHC:Human tonsil |
| Dilution | WB 1:500-1:2000;IHC 1:25-1:50 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human HRAS |
| Abbre | HRAS |
| Synonyms | C BAS/HAS;c H ras;C HA RAS1;c has/bas p21 protein;c ras Ki 2 activated oncogene;c-H-ras;CTLO;GTP and GDP binding peptide B;GTPase HRas;N-terminally processed;H Ras 1;H RASIDX;H-Ras-1;Ha Ras;Ha Ras1 proto oncoprotein;Ha-Ras;HAMSV;Harvey rat sarcoma viral oncogene homolog;Harvey rat sarcoma viral oncoprotein;HRAS;HRAS1;K ras;N ras;p19 H RasIDX protein;p21ras;Ras family small GTP binding protein H Ras;RASH;RASH1;Transformation gene oncogene HAMSV;Transforming protein p21;v Ha ras Harvey rat sarcoma viral oncogene homolog;VH Ras;vHa RAS抗体 |
| Swissprot | |
| Calculated MW | 21 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cell membrane. Golgi apparatus membrane. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. |
| Concentration | 0.66 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction |
| Conjugation | Unconjugated |
| Background | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
Western blot analysis of Mouse brain tissue SKOV3 cell Rat brain tissue Mouse kidney tissue lysates using HRAS Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human tonsil tissue using HRAS Polyclonal Antibody at dilution of 1:25(×200)
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
