HRAS Polyclonal Antibody
规格: | / 20μL / 60μL / 120μL / 200μL |
价格: | / ¥420 / ¥1010 / ¥1640 / ¥2365 |
货号:E-AB-40406
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
Synonyms | C BAS/HAS, C HA RAS1, CTLO, H Ras 1, H RASIDX, HAMSV, HRAS1, Harvey rat sarcoma viral oncogene homolog, K ras, N ras, p19 H RasIDX protein, p21ras, RASH1, Transforming protein p21, vHa RAS,HRAS抗体 |
Swissprot | P01112 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | Recombinant Human GTPase HRas protein |
Application | IHC(Detection kit: E-IR-R213) |
Recommended dilution | IHC,,1:100-1:300; |
Concentration | 0.78mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
Background | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
Images
Immunohistochemistry of paraffin-embedded Human prostate gland using HRAS Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human kidney cancer using HRAS Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human stomach using HRAS Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Mouse colon using HRAS Polycloanl Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Rat colon using HRAS Polycloanl Antibody at dilution of 1:200