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HRAS Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-40406

宿主: Rabbit

反应性: H,M,R

应用: IHC

  • 详情
  • Overview

    Synonyms C BAS/HAS, C HA RAS1, CTLO, H Ras 1, H RASIDX, HAMSV, HRAS1, Harvey rat sarcoma viral oncogene homolog, K ras, N ras, p19 H RasIDX protein, p21ras, RASH1, Transforming protein p21, vHa RAS,HRAS抗体
    Swissprot P01112
    Source Rabbit
    Reactivity Human,Mouse,Rat
    Immunogen Recombinant Human GTPase HRas protein
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:100-1:300;
    Concentration 0.78mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
    Background This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
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