PTEN Polyclonal Antibody
规格: | / 60μL / 120μL / 200μL |
价格: | / ¥1380 / ¥2220 / ¥3300 |
货号:E-AB-70070
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
Synonyms | 10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog,Phosphatase and tensin like protein,Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,Pten,PTEN,PTEN1,TEP1,PTEN抗体 |
Swissprot | P60484,O08586 |
Source | Rabbit |
Reactivity | Human,Mouse |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse PTEN |
Application | IHC(Detection kit: E-IR-R213) |
Recommended dilution | IHC,,1:100-1:500; |
Concentration | 480 μg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Secreted. May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif and Cytoplasm. Nucleus. Nucleus, PML body. Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization. |
Tissue specificity | Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.Highest expression level in intestine. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Background | PTEN (also designated MMAC1),products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol. |
Images
Immunohistochemistry analysis of paraffin-embedded human stomach using PTEN Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded mouse lung using PTEN Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded Human Pancreas using PTEN Polyclonal Antibody(Elabscience® Product Detected by Lifespan).