本公司产品仅供体外研究使用,不用于临床诊断

PTEN Polyclonal Antibody

规格: / 60μL / 120μL / 200μL
价格: / ¥1380 / ¥2220 / ¥3300

货号:E-AB-70070

宿主: Rabbit

反应性: H,M

应用: IHC

  • 详情
  • Overview

    Synonyms 10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog,Phosphatase and tensin like protein,Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,Pten,PTEN,PTEN1,TEP1,PTEN抗体
    Swissprot P60484,O08586
    Source Rabbit
    Reactivity Human,Mouse
    Immunogen KLH conjugated Synthetic peptide corresponding to Mouse PTEN
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:100-1:500;
    Concentration 480 μg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Secreted. May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif and Cytoplasm. Nucleus. Nucleus, PML body. Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization.
    Tissue specificity Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.Highest expression level in intestine.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
    Background PTEN (also designated MMAC1),products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
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