Recombinant Human PPP1R14A Protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： Q96A00
| 别称 |
Protein Phosphatase 1 Regulatory Subunit 14A;17 kDa PKC-Potentiated Inhibitory Protein of PP1;Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa;CPI-17;PPP1R14A;CPI17;PPP1INL
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| 表达系统 |
E.coli
|
| 序列 |
Met 1-Pro147
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| 蛋白编码 |
Q96A00
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| 种属 |
Human
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| 计算分子量 |
17.8 kDa
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| 表观分子量 |
23-26 kDa
|
| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.2mM EDTA, 1mM DTT, 10% Glycerol, pH 8.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime; PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated; PPP1R14A has over 1000-fold higher inhibitory activity; creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition; inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
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实验操作视频
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