Recombinant Human SRC/Proto-oncogene c-Src Protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： P12931-1
| 别称 |
Proto-oncogene tyrosine-protein kinase Src;Proto-oncogene c-Src;pp60c-src;p60-Src;SRC1
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| 表达系统 |
E.coli
|
| 序列 |
Gly2-Gly287
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| 蛋白编码 |
P12931-1
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| 种属 |
Human
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| 计算分子量 |
31.2 kDa
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| 表观分子量 |
32.4 kDa
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| 标签 |
N-His
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
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| 内毒素 |
Please contact us for more information.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
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实验操作视频
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