SMAD4 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主： Rabbit
- 反应性： Human;Mouse
- 应用性： WB
| Verified Samples |
Verified Samples in WB:Hela,A431,HCT116,Mouse lung,Mouse stomach |
| Dilution | WB 1:500-1:2000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Smad4 |
| Abbre | SMAD4 |
| Synonyms | (Small) Mothers Against Decapentaplegic;Deleted in Pancreatic Carcinoma 4;Deleted in Pancreatic Carcinoma;Deleted in pancreatic carcinoma locus 4;Deletion target in pancreatic carcinoma 4;DPC 4;DPC4;hSMAD4;JIP;MAD homolog 4;MAD mothers against decapentaplegic Drosophila homolog 4;MAD mothers against decapentaplegic homolog 4;MADH 4;MADH4;Med;Medea;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic;Drosophila;homolog of;4;Mothers against DPP homolog 4;MYHRS;OTTHUMP00000163548;SMA- and MAD-related protein 4;SMAD 4;SMAD family member 4;SMAD mothers against DPP homolog 4;SMAD4;SMAD4抗体 |
| Swissprot | |
| Calculated MW | 60-70kDa |
| Observed MW | 70kDa |
| Cellular Localization | Cytoplasm, Nucleus |
| Concentration | 0.62 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction; Stem Cells |
| Conjugation | Unconjugated |
| Background | This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
SMAD4 (SMAD Family Member 4) is a Protein Coding gene. Diseases associated with SMAD4 include Myhre Syndrome and Polyposis, Juvenile Intestinal. Among its related pathways are PEDF Induced Signaling and Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SMAD9. |
Western Blot analysis of various samples using SMAD4 Polyclonal Antibody at dilution of 1:1000.
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
