SOCS1 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB:231 Verified Samples in IHC:Human ovarian cancer,Human gastric cancer |
Dilution | WB 1:1000-1:5000;IHC 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthetic peptide of human SOCS1 |
Abbre | SOCS1 |
Synonyms | CISH 1;CISH1;Cytokine inducible SH2 protein 1;JAB;JAK binding protein;JAK-binding protein;Janus kinase binding protein;SOCS 1;SOCS-1;Socs1;SOCS1;SSI 1;SSI-1;SSI1;STAT induced STAT inhibitor 1;STAT-induced STAT inhibitor 1;Suppressor of cytokine signaling 1;Supressor of cytokine signalling 1;TEC interacting protein 3;Tec-interacting protein 3;TIP 3;TIP-3;TIP3抗体 |
Swissprot | |
Calculated MW | 24kDa |
Cellular Localization | Cytosol,Nucleus,nucleoplasm,Other locations:cytoplasm,cytoplasmic ribonucleoprotein granule,cytoplasmic vesicle |
Concentration | 0.7 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction |
Conjugation | Unconjugated |
Background | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
Western Blot analysis of 231 cell using SOCS1 Polyclonal Antibody at dilution of 1:1300
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SOCS1 Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human gastric cancer using SOCS1 Polyclonal Antibody at dilution of 1:70
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E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |