TIMP2 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IF
| Verified Samples |
Verified Samples in WB:A549,293T,Mouse spleen,Mouse lung,Mouse brain,Rat lung Verified Samples in IF: C6, U-2OS |
| Dilution | WB 1:500-1:2000;IF 1:50-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide of human TIMP2 (NP_003246.1). |
| Abbre | TIMP2 |
| Synonyms | TIMP2;CSC-21K;DDC8抗体 |
| Swissprot | |
| Calculated MW | 24kDa |
| Observed MW | 26kDa |
| Cellular Localization | Secreted. |
| Concentration | 1mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer; Cell Biology; Cardiovascular; Signal Transduction |
| Conjugation | Unconjugated |
| Background | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. |
Western blot analysis of extracts of various cell lines using TIMP2 Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of C6 cells using TIMP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U-2 OS cells using TIMP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
