TNK2 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB:231 Verified Samples in IHC:Human breast cancer,Human liver cancer |
Dilution | WB 1:1000-1:5000;IHC 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthetic peptide of human TNK2 |
Abbre | TNK2 |
Synonyms | Acetate kinase 1;Acetokinase 1;ACK 1;ACK;ACK-1;ACK1;ACK1;Activated Cdc42 associated kinase 1;Activated CDC42 kinase 1;Activated p21cdc42Hs kinase;FLJ44758;FLJ45547;p21cdc42Hs;TNK 2;TNK2;Tyrosine kinase non receptor 2;Tyrosine kinase non receptor protein 2;Tyrosine kinase non-receptor protein 2抗体 |
Swissprot | |
Calculated MW | 119kDa |
Cellular Localization | Cell membrane. Nucleus. Endosome. Cell junction>adherens junction. Cytoplasmic vesicle membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes. |
Concentration | 0.6 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Epigenetics and Nuclear Signaling; Signal Transduction |
Conjugation | Unconjugated |
Background | This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. |
Western Blot analysis of 231 cell using TNK2 Polyclonal Antibody at dilution of 1:1800
Immunohistochemistry of paraffin-embedded Human breast cancer using TNK2 Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human liver cancer using TNK2 Polyclonal Antibody at dilution of 1:70
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E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |