ACE2 Polyclonal Antibody
规格: | / 60μL / 120μL / 200μL |
价格: | / ¥1380 / ¥2220 / ¥3300 |
货号:E-AB-70126
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
Synonyms | ACE 2,ACE related carboxypeptidase,ACE-related carboxypeptidase,ACE2,ACE2,ACEH,Angiotensin converting enzyme 2,Angiotensin converting enzyme homolog,Angiotensin converting enzyme like protein,Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2,Angiotensin I converting enzyme 2,Angiotensin-converting enzyme homolog,DKFZP434A014,EC 3.4.17,metalloprotease MPROT 15,Metalloprotease MPROT15,OTTHUMP00000022963,Processed angiotensin-converting enzyme 2,ACE2抗体 |
Swissprot | Q9BYF1,Q8R0I0,Q5EGZ1 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse ACE2 |
Application | WB(Detection kit: E-IR-R304) |
Recommended dilution | WB,,1:500-1:2000; |
Concentration | 330 μg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Secreted and Cell membrane. |
Tissue specificity | Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.Highest expression level in jejunal mucosa. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Background | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. |