FOXO1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70143
宿主: Rabbit
反应性: M,R
应用: WB
Overview
| Synonyms | FKH 1,FKH1,FKHR,Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma),Forkhead box O1,Forkhead box protein O1,Forkhead box protein O1A,Forkhead in rhabdomyosarcoma,Forkhead,Drosophila,homolog of,in rhabdomyosarcoma,FoxO transcription factor,foxo1,FOXO1,FOXO1A,OTTHUMP00000018301,FOXO1抗体 |
| Swissprot | Q9R1E0,G3V7R4 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse FOXO1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.58 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus. |
| Tissue specificity | Expressed in liver, white and brown adipose tissues (at protein level).Highest expression level in female gonad. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2). |
