Human TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
人肿瘤坏死因子α(TNF-α)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥2400 / ￥1650 / ￥10200 |
货号：E-EL-H0109
反应性: 人
检测范围: 7.81~500 pg/mL
灵敏度: 4.69 pg/mL
用途
该试剂盒用于体外定量检测人serum, plasma and other biological fluids中TNF-α浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗人TNF-α抗体包被于酶标板上，实验时样品或标准品中的人TNF-α会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗人TNF-α抗体和辣根过氧化物酶标记的亲和素。抗人TNF-α抗体与结合在包被抗体上的人TNF-α结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，TNF-α浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中TNF-α的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 人 |
| 检测方法 | Colormetric |
| 检测范围 | 7.81—500 pg/mL |
| 灵敏度 | 4.69 pg/mL |
| 样本体积 | 100μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的人TNF-α，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 500 | 2.427 2.445 |
2.436 | 2.376 |
| 250 | 1.562 1.584 |
1.573 | 1.513 |
| 125 | 0.993 0.979 |
0.986 | 0.926 |
| 62.5 | 0.477 0.515 |
0.496 | 0.436 |
| 31.25 | 0.245 0.237 |
0.241 | 0.181 |
| 15.63 | 0.166 0.16 |
0.163 | 0.103 |
| 7.81 | 0.105 0.121 |
0.113 | 0.053 |
| 0 | 0.059 0.061 |
0.06 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
24.10 | 79.50 | 183.00 | 22.70 | 86.50 | 177.40 |
| Standard
deviation |
1.50 | 3.80 | 9.70 | 1.20 | 4.00 | 7.60 |
| C V (%) | 6.22 | 4.78 | 5.30 | 5.29 | 4.62 | 4.28 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 86-100 | 92 |
| EDTA plasma (n=5) | 94-106 | 99 |
| Cell culture media (n=5) | 93-107 | 99 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 92-105 | 84-97 | 88-99 |
| Average (%) | 99 | 91 | 93 | |
| 1:4 | Range (%) | 99-116 | 87-99 | 91-104 |
| Average (%) | 107 | 93 | 98 | |
| 1:8 | Range (%) | 97-113 | 81-93 | 92-109 |
| Average (%) | 104 | 88 | 99 | |
| 1:16 | Range (%) | 96-112 | 85-98 | 95-107 |
| Average (%) | 103 | 90 | 100 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: Cell culture supernatant - 文献: Role of CD36 rs1761667 AA genotype in the expression of inflammatory cytokines and Parkinson’s disease progression: A case-control study in a northern Han Chinese population
样品类型: plasma - 文献: Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis
样品类型: serum - 文献: LncRNA MALAT1 promotes relapse of breast cancer patients with postoperative fever
样品类型: plasma - 文献: Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1β, and TNFα levels in type 2 diabetes and insulin resistance
样品类型: serum - 文献: IL-16 regulates macrophage polarization as a target gene of mir-145-3p
样品类型: Cell lysate - 文献: Circ_USP36 Silencing Attenuates Oxidized Low-Density Lipoprotein-Induced Dysfunction in Endothelial Cells in Atherosclerosis Through Mediating miR-197-3p/ROBO1 Axis
样品类型: HUVEC cells - 文献: Cytokine profile during pregnancy predicts relapses during pregnancy and postpartum in multiple sclerosis
样品类型: serum - 文献: S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway
样品类型: Cell culture supernatant - 文献: Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism
样品类型: HepG2 cells - 文献: Molecular characterization and functional analysis of MyD88 from the tropical sea cucumber, Holothuria leucospilota
样品类型: HEK293T cells - 文献: The Pharmaceutical Device Prisma® Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing
样品类型: Cell culture supernatant - 文献: Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study
样品类型: Serum - 文献: LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203
样品类型: Cell culture supernatant - 文献: Effect of Ramadan diurnal fasting on visceral adiposity and serum adipokines in overweight and obese individuals
样品类型: Serum - 文献: Oxidative Burst of Circulating Neutrophils Following Traumatic Brain Injury in Human
样品类型: Plasma - 文献: Clinical characteristics and outcomes of COVID-19 patients in Bali, Indonesia
样品类型: serum - 文献: Regulatory Effects of Fyn on Trophoblast Cell Behaviors and Function
样品类型: HTR-8/SVneo cells,JEG-3 cells - 文献: Human cytomegalovirus infection is correlated with atherosclerotic plaque vulnerability in carotid artery
样品类型: Serum - 文献: Nintedanib ameliorates oxidized low-density lipoprotein -induced inflammation and cellular senescence in vascular endothelial cells
样品类型: HUVECs - 文献: N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and
样品类型: BEAS-2B cell - 文献: Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes
样品类型: HaCaT cell - 文献: Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis
样品类型: Human retinal microvascular endothelial cell (HRECs) - 文献: Carvedilol activates nuclear factor E2-related factor 2/ antioxidant response element pathway to inhibit oxidative stress and apoptosis of retinal pigment epithelial cells induced by high glucose
样品类型: ARPE-19 cell - 文献: DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway
样品类型: THP-1 cells - 文献: Gold nanoparticles loaded TNF-α and CALNN peptide as a drug delivery system and promising therapeutic agent for breast cancer cells
样品类型: MCF-7 cell,AMJ-13 cell - 文献: Comparison of delta-tocotrienol and alpha-tocopherol effects on hepatic steatosis and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: A randomized double-blind active-controlled trial
样品类型: serum - 文献: MiRNA505/NET1 Axis Acts as a CD8+ T-TIL Regulator in Non-Small Cell Lung Cancer
样品类型: Cell culture supernatant - 文献: Sublethal effects of zinc oxide nanoparticles on male reproductive cells
样品类型: Cell culture supernatant - 文献: Cancer cell-derived exosomal LINC00313 induces M2 macrophage differentiation in non-small cell lung cancer
样品类型: THP-1 cell,H1299 cell - 文献: A Novel 7-Days Prolonged Dietary Deprivation Regimen Improves ALT and UA After 3–6 Months Refeeding, Indicating Therapeutic Potential
样品类型: serum - 文献: iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction
样品类型: Serum,Cell sample - 文献: Assessment of Unstimulated Whole Salivary Tumor Necrosis Factor Alpha (TNF-α) and Cellular Micronuclei Levels in Snuff (Naswar) Users and Non-Users for Early Diagnosis of Oral Squamous Cell Carcinoma
样品类型: saliva - 文献: Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis
样品类型: Cell culture supernatant - 文献: Cul4a attenuates LPS-induced acute kidney injury via blocking NF-kB signaling pathway in sepsis
样品类型: HK-2 cell - 文献: Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology
样品类型: Cell culture supernatant - 文献: Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway
样品类型: sputum - 文献: Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling
样品类型: rheumatoid arthritis (RA) fibroblast-like synoviocytes - 文献: The Value of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) in Predicting the Severity and Prognosis of Patients After Cardiac Arrest: A Preliminary Observational Study
样品类型: serum - 文献: Association between pro-inflammatory cytokines in cerebrospinal fluid and headache in patients with aneurysmal subarachnoid hemorrhage
样品类型: cerebrospinal fluid (CSF) - 文献: (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages
样品类型: Cell culture supernatant - 文献: Sarcococca saligna Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund’s Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers
样品类型: serum - 文献: Nanoparticles as a novel tool to inhibit inflammatory cytokines in human lymphocytes and macrophages of coronary artery disease
样品类型: Lymphocytes,macrophages - 文献: Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1
样品类型: SH-SY5Y cell - 文献: Early Diagnosis of Coronary Artery Disease by Inflammatory Biomarkers of Atherosclerosis in Patients with Angina
样品类型: serum - 文献: Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?
样品类型: fecal - 文献: strain FP10
样品类型: Cell culture supernatant - 文献: Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways
样品类型: Serum,Cell culture supernatant - 文献: Sapylin (OK-432) alters inflammation and angiogenesis in vivo and vitro
样品类型: Wound drainage fluid - 文献: Chronic fatigue and fibromyalgia symptoms are key components of deficit schizophrenia and are strongly associated with activated immune-inflammatory pathways
样品类型: Serum - 文献: Role of non-neuronal cholinergic system in the early stage response of epithelial-mesenchymal transformation related markers in A549 cells induced by coal particles
样品类型: A549 cell - 文献: Establishing SW1353 Chondrocytes as a Cellular Model of Chondrolysis
样品类型: SW1353 cell - 文献: Tocilizumab attenuates acute lung and kidney injuries and improves survival in a rat model of sepsis via down-regulation of NF-κB/JNK: a possible role of P-glycoprotein
样品类型: Serum - 文献: Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.
样品类型: Serum - 文献: Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
样品类型: THP-1 cell - 文献: Combination of oncolytic adenovirus ZD55 harboring TRAIL-IETD-MnSOD and cytokine-induced killer cells against lung cancer
样品类型: serum,BEAS-2B cell - 文献: A simple lectin-based biochip might display the potential clinical value of glycomics in patients with spontaneous intracerebral hemorrhage
样品类型: serum - 文献: Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice
样品类型: Cell culture supernatant - 文献: Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome
样品类型: serum - 文献: MiRNA-126 expression inhibits IL-23R mediated TNF-α or IFN-γ production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis
样品类型: Serum - 文献: HDAC1 promotes artery injury through activation of VAV3 by binding to miR-182-5p in atherosclerotic mice model
样品类型: Cell culture supernatant - 文献: Silencing of UCA1 Protects Against MPP+-Induced Cytotoxicity in SK-N-SH Cells via Modulating KCTD20 Expression by Sponging miR-423-5p
样品类型: Cell culture supernatant - 文献: Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits
样品类型: Cell culture supernatant - 文献: The effect of different dietary ratios of arginine, methionine, and lysine on the performance, carcass traits, and immune status of turkeys
样品类型: Plasma - 文献: Serum irisin level in myocardial infarction patients with or without heart failure
样品类型: serum - 文献: Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users:
样品类型: Plasma - 文献: Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway
样品类型: Cell culture supernatant - 文献: Auto-reactivity against gut bacterial peptides in patients with late-onset diabetes
样品类型: Serum - 文献: Correlation of Inflammation and Coagulation Markers with the Incidence of Deep Vein Thrombosis in Cancer Patients with High Risk of Thrombosis
样品类型: plasma - 文献: Intermittent hypoxia induces tumor immune escape in murine S180 solid tumors via the upregulation of TGF-β 1 in mice
样品类型: Tissue homogenate - 文献: Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia
样品类型: salivary - 文献: Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori‐infected patients
样品类型: Cell culture supernatant - 文献: Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas
样品类型: serum - 文献: Evaluation of malnutrition and inflammation after total parathyroidectomy in patients on maintenance dialysis
样品类型: serum - 文献: Blood Monocyte Phenotype Fingerprint of Stable Coronary Artery Disease: A Cross-Sectional Substudy of SMARTool Clinical Trial
样品类型: serum - 文献: Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial
样品类型: blood - 文献: Roles and mechanisms of NRG1 in modulating the pathogenesis of NAFLD through ErbB3 signaling in hepatocytes (NRG1 modulates NAFLD through ErbB3 signaling)
样品类型: Cell culture supernatant - 文献: The abnormal distribution of peripheral B1 cells and transition B cells in patients with idiopathic dilated cardiomyopathy: a pilot study
样品类型: plasma - 文献: MicroRNA-33-5p inhibits cholesterol efflux in vascular endothelial cells by regulating citrate synthase and ATP-binding cassette transporter A1
样品类型: VEC - 文献: Analysis of serum cytokine and protective vitamin D levels in severe cases of COVID-19
样品类型: serum - 文献: The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes
样品类型: urinary,serum - 文献: Circ_0043947 contributes to interleukin 1β-induced injury in chondrocytes by sponging miR-671-5p to up-regulate RTN3 expression in osteoarthritis pathology
样品类型: chondrocytes - 文献: C reactive protein and enzymatically modified LDL cooperatively promote dendritic cell-mediated T cell activation
样品类型: Cell culture supernatant - 文献: The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis
样品类型: blood - 文献: Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells
样品类型: Cell lysate - 文献: Study of Metal-Metal Interactions and Their Biomarkers Using an Intestinal Human Cell Line
样品类型: Cell lysate - 文献: Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
样品类型: serum - 文献: Comparison of safety, effectiveness and serum inflammatory factor indexes of Saccharomyces boulardii versus Bifidobacterium triple viable in treating children with chronic diarrhea: a randomized trial
样品类型: serum - 文献: LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis
样品类型: HCnEpCs - 文献: Obstructive sleep apnea in children with hypothalamic obesity: Evaluation of possible related factors
样品类型: Plasma - 文献: Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study
样品类型: serum - 文献: XIST silencing alleviated inflammation and mesangial cells proliferation in diabetic nephropathy by sponging miR-485
样品类型: Serum - 文献: Isolation, characterization and analysis of pro-inflammatory potential of Klebsiella pneumoniae outer membrane vesicles
样品类型: Cell culture supernatant - 文献: The Anti-Inflammatory Effect of Callicarpa nudiflora Extract on H. Pylori-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1 β Signaling Axis
样品类型: GES-1 cell - 文献: The effects of blood purification combined with antibiotics on extravascular lung water index, inflammatory factors, and prognosis of patients with severe acute pancreatitis complicated with acute respiratory distress syndrome.
样品类型: blood - 文献: Effect of probiotics supplementation combined with WeChat platform health management on nutritional status, inflammatory factors, and quality of life in patients with mild-to-moderate ulcerative colitis: a randomized trial.
样品类型: serum - 文献: Intercalation of shRNA-plasmid in Mg–Al layered double hydroxide nanoparticles and its cellular internalization for possible treatment of neurodegenerative diseases
样品类型: SH-SY5Y cells - 文献: Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study:
样品类型: serum - 文献: The Anti-Inflammatory Effect of Smilax china L. Extract on LPS-Stimulated THP-1 via Downregulation of MAPK and NF-κB Signaling Pathway
样品类型: THP-1 cells - 文献: Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197
样品类型: Human Umbilical Vein Endothelial Cells (HUVECs) - 文献: Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6.
样品类型: Human nasal epithelial cell (hNECs) - 文献: Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors
样品类型: serum - 文献: PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells
样品类型: macrophage - 文献: Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke
样品类型: SK-N-SH cells - 文献: Biochemical Mapping of the Inflamed Human Dental Pulp
样品类型: dental pulp lysates - 文献: Assessment of Mineralization, Oxidative Stress, and Inflammation Mechanisms in the Pulp of Primary Teeth
样品类型: Dental pulp tissue - 文献: Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2
样品类型: HK-2 cell - 文献: Long non-coding RNA MEG3 regulates CSE-induced apoptosis and inflammation via regulating miR-218 in 16HBE cells
样品类型: Cell culture supernatant - 文献: Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels
样品类型: Serum - 文献: Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
样品类型: Plasma - 文献: A randomized controlled trial: Comparison of one-per-mil tumescent technique and tourniquet in surgery for burn hand contracture in creating clear operative field and assessment of functional outcome
样品类型: plasma - 文献: Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1–7) upregulation
样品类型: Cell culture supernatant,Serum - 文献: High anti-human cytomegalovirus antibody levels are associated with the progression of essential hypertension and target organ damage in Han Chinese population
样品类型: Serum - 文献: Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages
样品类型: THP-1 cell - 文献: XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway
样品类型: HRGECs - 文献: Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors
样品类型: Serum - 文献: Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?
样品类型: serum - 文献: Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats
样品类型: Kidney tissue - 文献: Fluorometholone inhibits high glucose-induced cellular senescence in human retinal endothelial cells:
样品类型: human retinal endothelial cell - 文献: Transforming growth factor‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p
样品类型: Cell culture supernatant - 文献: Effect of Helicobacter pylori-eradication therapy on hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomized–controlled pilot study
样品类型: Serum - 文献: Identification of key genes and crucial pathways for major depressive disorder using peripheral blood samples and chronic unpredictable mild stress rat models
样品类型: plasma - 文献: Human cytomegalovirus infection and its association with gestational diabetes mellitus during pregnancy
样品类型: serum - 文献: A novel human anti-TIGIT monoclonal antibody with excellent function in eliciting NK cell-mediated antitumor immunity
样品类型: Cell culture supernatant - 文献: The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study
样品类型: serum - 文献: Major Depression in Children with Transfusion-Dependent Thalassemia Is Strongly Associated with the Combined Effects of Blood Transfusion Rate, Iron Overload, and Increased Pro-inflammatory Cytokines
样品类型: Serum - 文献: Association of High Mobility Group Box Protein B1 Gene Polymorphisms with Pneumonia Susceptibility and Severity
样品类型: Plasma - 文献: Effects of Edaravone on Neurological Function and Tumor Necrosis Factor Alpha and Interleukin 8 Levels in Patients with Cerebral Infarction
样品类型: serum - 文献: Inhibition of miR‑27a suppresses the inflammatory response via the p38/MAPK pathway in intervertebral disc cells
样品类型: Cell culture supernatant - 文献: A label-free and sensitive impedimetric immunosensor for TNF α biomarker detection based on epoxysilane-modified disposable ITO-PET electrode
样品类型: Immunosensor Construction - 文献: HMGB‐1, TLR4, IL‐1R1, TNF‐α, and IL‐1β: novel epilepsy markers?
样品类型: serum - 文献: Effect of laparoscopic sleeve gastrectomy on renal function in obese patients
样品类型: Serum,Urine - 文献: Correlation Between Single Nucleotide Polymorphisms at the 3′-UTR of the NFKB1 Gene and Acute Kidney Injury in Sepsis
样品类型: Cell sample - 文献: MicroRNA-124 alleviates hyperoxia-induced inflammatory response in pulmonary epithelial cell by inhibiting TLR4/NF-κB/CCL2
样品类型: Beas2B cells - 文献: Role of miR‑589‑3p in human lumbar disc degeneration and its potential mechanism
样品类型: Cell culture supernatant - 文献: N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway
样品类型: peripheral blood - 文献: Leukocyte depletion does not affect the in vitro healing ability of platelet rich plasma
样品类型: Cell culture supernatant - 文献: Anti‑inflammatory effect of Resolvin D1 on LPS‑treated MG‑63 cells Corrigendum in /10.3892/etm.2019.8021
样品类型: Serum - 文献: Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period
样品类型: Plasma - 文献: Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Murine Model: Protective Effect of Cyclosporine-A
样品类型: Serum - 文献: Clinical Efficacy and Possible Mechanism of Endoscopic Vidian Neurectomy for House Dust Mite-Sensitive Allergic Rhinitis
样品类型: serum - 文献: Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages
样品类型: Cell culture supernatant - 文献: Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses
样品类型: Cell culture supernatant - 文献: miR-1287-5p upregulation inhibits the EMT and pro-inflammatory cytokines in LPS-induced human nasal epithelial cells (HNECs)
样品类型: HNECs cells - 文献: Systematically transplanted human gingiva‑derived mesenchymal stem cells regulate lipid metabolism and inflammation in hyperlipidemic mice with periodontitis
样品类型: Serum - 文献: Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF‑α‑mediated osteoclast autophagy
样品类型: Cell culture supernatant - 文献: Application of dexmedetomidine-assisted intravertebral anesthesia in hip replacement and its influence on T-lymphocyte subsets
样品类型: serum - 文献: Rhubarb-Aconite Decoction (RAD) Drug-Containing Serum Alleviated Endotoxin-Induced Oxidative Stress Injury and Inflammatory Response in Caco-2 Cells In Vitro
样品类型: Cell culture supernatant - 文献: Decreased monocyte subsets and TLR4-mediated functions in patients with acute severe fever with thrombocytopenia syndrome (SFTS)
样品类型: Cell culture supernatant - 文献: TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes
样品类型: plasma - 文献: A case-control study on the relationship between miRNAs single nucleotide polymorphisms and sepsis risk
样品类型: Serum - 文献: Sinomenine Regulates Inflammatory Response and Oxidative Stress via Nuclear Factor kappa B (NF-κB) and NF-E2-Related Factor 2 (Nrf2) Signaling Pathways in Ankle Fractures in Children
样品类型: Serum - 文献: Propofol Promotes Ankle Fracture Healing in Children by Inhibiting Inflammatory Response
样品类型: Serum - 文献: Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments
样品类型: Serum - 文献: Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells
样品类型: Cell culture supernatant - 文献: The shortening telomere length of T lymphocytes maybe associated with hyper‑function in servere aplastic anemia
样品类型: Cell culture supernatant - 文献: Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1
样品类型: Cell culture supernatant - 文献: In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera
样品类型: Cell culture supernatant - 文献: Comparison of the Cytokine Profile in Mesenchymal Stem Cells from Human Adipose, Umbilical Cord, and Placental Tissues
样品类型: mesenchymal stem cells (MSCs) - 文献: The Escalation of Osteosarcoma Stem Cells Apoptosis After the Co-Cultivation of Peripheral Blood Mononuclear Cells Sensitized with Mesenchymal Stem Cells Secretome and Colony Stimulating Factor-2 in vitro
样品类型: OS-SCs cells - 文献: The effects of aerobic exercise and sertraline on pro-inflammatory indices and amelioration of neurotrophic factors in patients who have undergone CABG
样品类型: plasma,serum - 文献: Potential and Alternative Bioactive Compounds from Brown Agaricus bisporus Mushroom Extracts for Xerosis Treatment
样品类型: HaCaT cells - 文献: MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy
样品类型: plasma - 文献: Long-Term Resistance–Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity
样品类型: serum - 文献: Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
样品类型: Serum - 文献: Demonstration of gut-barrier dysfunction in early stages of non-alcoholic fatty liver disease: A proof-of-concept study
样品类型: serum - 文献: Oxidative stress index can be a new marker related to disease severity in COVID-19
样品类型: serum - 文献: Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly
样品类型: serum - 文献: Clinical efficacy and inflammatory factors in knee osteoarthritis with glucosamine hydrochloride plus meloxicam
样品类型: serum - 文献: TLR7 mediates increased vulnerability to ischemic acute kidney injury in diabetes
样品类型: Cell culture supernatant
