MS Mouse IL-10(Interleukin 10) ELISA Kit
MS-小鼠白介素10(IL-10)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥3080 / ￥2180 / ￥13860 |
货号：E-MSEL-M0031
反应性: 小鼠
检测范围: 15.63~1000 pg/mL
灵敏度: 9.13 pg/mL
MS系列
MS为Mini Sample的缩写。MS系列试剂盒的上样量仅为传统夹心法ELISA试剂盒的1/4，能有效解决实验样本体积不够的问题。Elabscience®自主开发的新技术，旨在帮助您以更高效的方式进行科学研究。
用途
该试剂盒用于体外定量检测小鼠serum, plasma and other biological fluids中IL-10浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗小鼠IL-10抗体包被于酶标板上，实验时样品或标准品中的小鼠IL-10会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗小鼠IL-10抗体和辣根过氧化物酶标记的亲和素。抗小鼠IL-10抗体与结合在包被抗体上的小鼠IL-10结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，IL-10浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中IL-10的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 小鼠 |
| 检测方法 | Colormetric |
| 检测范围 | 15.63—1000 pg/mL |
| 灵敏度 | 9.13 pg/mL |
| 样本体积 | 25μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的小鼠IL-10，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 1000 | 2.549 2.607 |
2.578 | 2.511 |
| 500 | 1.719 1.757 |
1.738 | 1.671 |
| 250 | 0.949 0.919 |
0.934 | 0.867 |
| 125 | 0.527 0.566 |
0.547 | 0.48 |
| 62.5 | 0.265 0.243 |
0.254 | 0.187 |
| 31.25 | 0.177 0.177 |
0.177 | 0.11 |
| 15.63 | 0.13 0.134 |
0.132 | 0.065 |
| 0 | 0.064 0.070 |
0.067 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
55.03 | 99.53 | 341.59 | 50.95 | 92.12 | 343.37 |
| Standard
deviation |
3.78 | 4.10 | 10.62 | 3.44 | 4.72 | 16.69 |
| C V (%) | 6.86 | 4.12 | 3.11 | 6.75 | 5.12 | 4.86 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 92-107 | 98 |
| EDTA plasma (n=5) | 92-103 | 98 |
| Cell culture media (n=5) | 91-104 | 97 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 86-96 | 93-107 | 89-101 |
| Average (%) | 91 | 100 | 96 | |
| 1:4 | Range (%) | 84-98 | 96-109 | 88-104 |
| Average (%) | 90 | 103 | 95 | |
| 1:8 | Range (%) | 81-94 | 92-104 | 88-102 |
| Average (%) | 88 | 97 | 94 | |
| 1:16 | Range (%) | 83-93 | 90-102 | 87-99 |
| Average (%) | 88 | 95 | 93 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: Tissue homogenate - 文献: NB‐UVB irradiation attenuates inflammatory response in psoriasis
样品类型: Serum - 文献: The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis
样品类型: Tissue homogenate - 文献: Plasmodium knowlesi Duffy binding protein alpha region II (PkDBPαII) in clinical isolates from Peninsular Malaysia and Malaysian Borneo exhibit different immune responses in animal models
样品类型: Spleen cell - 文献: HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation
样品类型: brain,serum - 文献: Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis
样品类型: Serum - 文献: Eosinophils attenuate arthritis by inducing M2 macrophage polarization via inhibiting the IκB/P38 MAPK signaling pathway
样品类型: Tissue homogenate,Cell culture supernatant - 文献: Metabolites of stable fly reduce diarrhea in mice by modulating the immune system, antioxidants, and composition of gut microbiota
样品类型: serum - 文献: Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury
样品类型: PVN tissue - 文献: Anti-Inflammatory and Immunomodulatory Role of Bone Marrow-Derived MSCs in Mice with Acute Lung Injury
样品类型: plasma - 文献: Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway
样品类型: serum - 文献: IL-37 alleviates alveolar bone resorption and inflammatory response through the NF-κB/NLRP3 signaling pathway in male mice with periodontitis
样品类型: periodontal tissue - 文献: Plasma Proteins As Biodosimetric Markers of Low-Dose Radiation in Mice:
样品类型: Plasma - 文献: IL-4 functionalized titanium dioxide nanotubes modulate the inflammatory response of macrophages
样品类型: RAW264.7 cell - 文献: Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes
样品类型: serum - 文献: Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury
样品类型: substantia nigra (SN) - 文献: The construction of recombinant Lactobacillus casei vaccine of PEDV and its immune responses in mice
样品类型: Serum - 文献: Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom
样品类型: Cell culture supernatant - 文献: Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells
样品类型: Cell culture supernatant - 文献: Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice
样品类型: Serum - 文献: Exposure time determines the protective effect of Trichinella spiralis on experimental colitis
样品类型: Serum - 文献: Curcumin ameliorates Staphylococcus aureus-induced mastitis injury through attenuating TLR2-mediated NF−κB activation
样品类型: Serum - 文献: The Hypermethylation of Foxp3 Promoter Impairs the Function of Treg Cells in EAP
样品类型: Serum - 文献: BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D‑deficient mice
样品类型: BMDCs - 文献: Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model
样品类型: serum - 文献: Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury
样品类型: serum - 文献: 3,4-dihydroxyphenylethyl alcohol glycoside reduces acetaminophen-induced acute liver failure in mice by inhibiting hepatocyte ferroptosis and pyroptosis
样品类型: plasma - 文献: Immunogenicity and protection against Glaesserella parasuis serotype 13 infection after vaccination with recombinant protein LolA in mice
样品类型: serum - 文献: Application of mouse model for evaluation of recombinant LpxC and GmhA as novel antigenic vaccine candidates of Glaesserella parasuis serotype 13
样品类型: serum - 文献: Immunomodulatory effect of papaya (Carica papaya) pulp and seed extracts as a potential natural treatment for bacterial stress
样品类型: Serum - 文献: An experimental hyperlipidemia model with periodontitis in mice
样品类型: serum - 文献: Evaluation of Allicin Against Alveolar Echinococcosis In Vitro and in a Mouse Model
样品类型: serum - 文献: Preadipocytes In Vitro
样品类型: Cell culture supernatant - 文献: Colonisation of mice and pigs by a chimeric porcine circovirus 1–2 prototype vaccine strain and a PCV2 isolate originating in China and their induction of cytokines
样品类型: Cell culture supernatant - 文献: Antioxidant and Anti-Inflammatory Activities of Kigelia africana (Lam.) Benth.
样品类型: RAW 264.7 cell - 文献: Alteration of Circadian Rhythms in 2D2 Transgenic Mice
样品类型: serum - 文献: Crocin Suppresses Inflammation-Induced Apoptosis in rmTBI Mouse Model Via Modulation of Nrf2 Transcriptional Activity
样品类型: brain cortex - 文献: Peroxisome proliferator-activated receptor-γ agonist pioglitazone fails to attenuate renal fibrosis caused by unilateral ureteral obstruction in mice
样品类型: Tissue homogenate
