ROCK2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52117
宿主: Rabbit
反应性: H,M,R
应用: WB,ELISA
Overview
| Synonyms | coiled-coil-containing protein kinase 2,KIAA0619,p164 ROCK 2,p164 ROCK-2,Rho associated coiled coil containing protein kinase 2,Rho associated protein kinase 2,Rho associated,coiled coil containing protein kinase II,Rho kinase 2,Rho-associated,Rho-associated protein kinase 2,ROCK 2,Rock II,Rock2,ROCK2,Rock2m,ROK alpha,ROKalpha,ROCK2抗体 |
| Swissprot | O75116 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human ROCK2 |
| Application | WB(Detection kit: E-IR-R304),ELISA |
| Recommended dilution | WB,,1:500-1:2000;ELISA,,1:5000-1:10000; |
| Concentration | 0.78mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. Cytoplasmic, and associated with actin microfilaments and the plasma membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. |
