CAV1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-30778
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC-p,IF,ELISA
Overview
| Synonyms | BSCL3,CAV,CAV1,CAV1,caveolae protein,22 kD,caveolin 1 alpha isoform,caveolin 1 beta isoform,Caveolin 1 caveolae protein 22kDa,Caveolin-1,Caveolin1,cell growth-inhibiting protein 32,CGL3,LCCNS,MSTP085,OTTHUMP00000025031,PPH3,VIP 21,VIP21,Caveolin-1抗体 |
| Swissprot | Q03135 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Caveolin-1 |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF,ELISA |
| Recommended dilution | WB,,1:500-2000;IHC,,1:50-300;IF,,1:50-300; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Golgi apparatus membrane. Cell membrane. Membrane>caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| Tissue specificity | Expressed in muscle and lung, less so in liver, brain and kidney. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. |
Images
Western Blot analysis of various cells using CAV1 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human stomach tissue using CAV1 Polyclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Rat kidney tissue using CAV1 Polyclonal Antibody at dilution of 1:200.
