E-Cadherin Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10198L
货期：咨询
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | CD324,CDH1,CDHE,UVO,CAM 120/80,Epithelial cadherin (CDH1),Uvomorulin |
| Swissprot | P12830 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Human E-Cadherin protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:1000;IHC,,1:100-1:200; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Tissue specificity | Non-neural epithelial tissues. |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,50% glycerol pH 7.4 |
| Background | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats,a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric,breast,colorectal,thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation,invasion,and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. |
Images
Western blot with E-Cadherin Polyclonal antibody at dilution of 1:1000.lane 1:Mouse spleen,lane 2:Rat brain
Immunohistochemistry of paraffin-embedded Human carcinoma of Colon using E-Cadherin Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human breast cancer using E-Cadherin Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human Placenta using E-Cadherin Polyclonal Antibody at dilution of 1:100(Elabscience Product)
Immunohistochemistry of paraffin-embedded Human ovarian cancer using E-Cadherin Polyclonal Antibody at dilution of 1:200
