FAK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12402
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,ELISA
Overview
| Synonyms | FADK 1,FADK,FAK related non kinase polypeptide,FAK1,FAK1,Focal adhesion kinase 1,Focal adhesion Kinase,Focal adhesion kinase isoform FAK Del33,Focal adhesion kinase related nonkinase,FRNK,p125FAK,pp125FAK,PPP1R71,Protein phosphatase 1 regulatory subunit 71,Protein tyrosine kinase 2,Protein-tyrosine kinase 2,Ptk2,PTK2 protein tyrosine kinase 2,PTK2抗体 |
| Swissprot | Q05397 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human PTK2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | WB,,1:2000-1:5000;IHC,,1:100-1:300; |
| Concentration | 1.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell junction>focal adhesion. Cell membrane. Constituent of focal adhesions. |
| Tissue specificity | Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. |
Images
Western Blot analysis of Mouse brain tissue using FAK Polyclonal Antibody at dilution of 1:1850
Immunohistochemistry of paraffin-embedded Human brain using FAK Polyclonal Antibody at dilution of 1:75
Immunohistochemistry of paraffin-embedded Human ovarian cancer using FAK Polyclonal Antibody at dilution of 1:75
