RBP3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40147
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | D10S64,D10S65,D10S66,Interphotoreceptor retinoid binding protein,Interphotoreceptor retinoid-binding protein,Interstitial retinol binding protein,Interstitial retinol-binding protein,IRBP,RBP 3,rbp3,RBPI,RET3,Retinol binding protein 3,Retinol binding protein 3 interstitial,Retinol-binding protein 3,RP66,RBP3抗体 |
| Swissprot | P10745 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant human Retinol-binding protein 3 protein |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:100; |
| Concentration | 2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix>interphotoreceptor matrix. Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Background | Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. |
