TNF alpha Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22116
宿主: Mouse
反应性: H,M,R
应用: WB,IHC-p
Overview
| Synonyms | APC1,APC1 protein,Cachectin,DIF,Differentiation inducing factor,Macrophage cytotoxic factor,Tnf,TNF superfamily,member 2,TNF,macrophage derived,TNF,monocyte derived,TNF-a,TNF-alpha,TNFA,TNFA,TNFSF2,Tumor necrosis factor alpha,Tumor necrosis factor,Tumor necrosis factor ligand superfamily member 2,Tumor Necrosis Factor,Membrane Form,Tumor necrosis factor,soluble form,TNF α抗体 |
| Swissprot | P01375 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:3000;IHC,,1:50-1:200; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Clone No | Clone:3D8 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. |
客户发表文献
- 文献: FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway
样品类型: Cell lysate,Tissue homogenate
