TPPP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18394
宿主: Rabbit
反应性: H,M
应用: WB,IHC,ELISA
Overview
| Synonyms | 25 kDa brain specific protein ,25 kDa brain-specific protein,Brain specific protein p25 alpha,Glycogen synthase kinase 3 (GSK3) inhibitor p24,OTTHUMP00000161630,p24,p25,p25-alpha,p25alpha ,TPPP,TPPP/p25,TPPP,TPPP1,Tubulin polymerization promoting protein,Tubulin polymerization-promoting protein,TPPP抗体 |
| Swissprot | O94811 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100;ELISA,,1:5000-1:10000; |
| Concentration | 0.8mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. |
Images
Western blot analysis of Human fetal brain tissue using TPPP Polyclonal Antibody at dilution of 1:250
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TPPP Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TPPP Polyclonal Antibody at dilution of 1:25(×200)
