WNK4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19365
宿主: Rabbit
反应性: H,M,R
应用: IHC,ELISA
Overview
| Synonyms | PHA 2B,PHA2B,PRKWNK 4,PRKWNK4,Protein kinase lysine deficient 4,Protein kinase lysine-deficient 4,Protein kinase with no lysine 4,Serine/threonine protein kinase WNK4,Serine/threonine-protein kinase WNK4,WNK lysine deficient protein kinase 4,Wnk4,WNK4,WNK4抗体 |
| Swissprot | Q96J92 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human WNK4 |
| Application | IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | IHC,,1:40-1:200;ELISA,,1:5000-1:10000; |
| Concentration | 1.32mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell junction, tight junction. Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. |
